Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting, Liver injury induced by paracetamol and challenges associated with intentional and unintentional use 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health ACETAMINOPHEN, SALICYLATES & NONSTEROIDAL ANTI INFLAMMATORY DRUGS