Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Epicatechin ameliorative effects on methotrexate induced hepatotoxicity in mice Reza Azadnasab, Hadi Kalantar, Layasadat Khorsandi, Heibatullah Kalantari, Mohammad Javad Khodayar, 2021 GlutathioneResponsive Methotrexate Polymersomes for Potential Management of Ectopic Pregnancy Mamnoon 2024 Small Wiley Online Library Busting the myth of methotrexate chronic hepatotoxicity Nature Reviews Rheumatology Whey protein concentrate ameliorates the methotrexate induced liver and kidney damage British Journal of Nutrition Cambridge Core Full article: L methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation
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glutathione and methotrexate Benefits of Liposomal Glutathione for Rheumatoid Arthritis