Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite Journal of Neuroscience Frontiers Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase 3 Activation: A Study With the Kinase Inhibitor Staurosporine There are many studies showing low Glutathione levels with Parkinson's and Alzheimer's disease. Also several studies show low glutathione is considered to be one of the early biochemical changes in both Parkinson's Hepatic transcriptome and proteome responses against diethyl maleate induced glutathione depletion in the rat Archives of Toxicology Springer Nature Link Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter Full article: Sulfur mustard triggers oxidative stress through glutathione depletion and altered expression of glutathione related enzymes in human airways