The Use and Potential Benefits of N Acetylcysteine in Non Acetaminophen Acute Liver Failure: An Etiology Based Review Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol an overview ScienceDirect Topics Tylenol's Impact on Glutathione and Liver Damage PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit