5 Factors that Deplete Glutathione Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Your Complete Guide to Glutathione Schoenwalder Health & Wellness Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Cell Death & Disease Glutathione Depletion: The Silent Driver of Aging Calibrate Hydration Glutathione, often dubbed the master antioxidant plays a crucial role in detoxification, immune function, and protecting our cells from oxidative stress. Here are some signs that your levels might be low: Persistent