The Difference Between Sunspots and Freckles and How to Care for Each Ornella Freckles vs Moles: How to Spot the Difference Freckles develop when specific skin cells produce extra melanin in response to sunlight. When ultraviolet rays reach the skin, melanocytes release melanin to protect deeper layers from damage. In some How to Tell the Difference Between a Mole and a Freckle Century Medical & Dental Center TC freckles sunspots moles Southern Cross University What's the difference between freckles, sunspots and moles?