Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Oral Mucosal Melanosis IntechOpen Random dark marks on lips : r Blackskincare Tiny brown spot on the lip? Don't ignore it. A melanotic macule is a small, well circumscribed brown to black oral lesion most commonly seen on the lower lip and a high yield ADC exam favourite. Oral Melanotic Macule MEDizzy Oral Melanotic Macule MEDizzy