USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol and Alcohol: Liver Damage Risks & Safety Tips Gratitude Lodge Acetaminophen Pathway (toxic doses), Pharmacokinetics