Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? What Are the Potential Sites of Protein Arylation by N Acetyl p benzoquinone Imine (NAPQI)? Chemical Research in Toxicology Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite Solved The stepwise mechanism below shows how glutathione Chegg.com