Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione deplet Integrative Biology (RSC Publishing) DOI:10.1039 C3IB20245C The acetaminophen metabolite N acetyl p benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mecha 5 Oxoprolinase an overview ScienceDirect Topics A yeast model of 5 oxoproline accumulation reveals a general toleration to 5 oxoproline bioRxiv Accumulation of 5 oxoproline in myocardial dysfunction and the protective effects of OPLAH Science Translational Medicine Glutathione Biochemistry Glutathione Synthesis Enzymes Glyteine
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5-oxoproline glutathione Full article: Identification of the γ-glutamyl cycle as a novel therapeutic target and 5-oxoproline as a new biomarker for diagnosing pancreatic cancer