Acetaminophen OpenAnesthesia Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Acetaminophen Overdose Concise Medical Knowledge Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.