SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis: Molecular Cell Carnitine: Top 3 Anti Aging Benefits of This Super Nutrient L carnitine is primarily synthesized in the liver from the amino acids lysine and methionine through a series of four enzymatic reactions, with the liver and kidneys converting the precursor butyrobetaine into active Carnitine_tekst Molecule of the Month September 2003 The Brain and Mitochondria Boosting Benefits of Acetyl L Carnitine (ALCAR) by Alex Leaf, M.S. The Energy Blueprint Mitochondrial diseases Nature Reviews Disease Primers