Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors glutathione Archives Genetic Lifehacks Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Can Tylenol (acetaminophen) deplete glutathione levels in the body? Acetaminophen Toxicity: OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE ScienceDirect