The Role of Food and Supplements in Detoxification During Lyme Disease Treatment The Stram Center Integrative Medicine, Functional Medicine, Albany NY Feeling worse before you feel better? It might be a Herx. Also called a Jarisch Herxheimer reaction, herxing happens when Lyme microbes are killed off and release toxins into your system, sparking a Herx Reaction RyDocs Die Off Reactions Handout Functional Health Research + Resources Made Whole Nutrition LYME SCI: The dreaded Jarisch Herxheimer reaction Lyme disease and tick borne diseases are complicated illnesses and because of that, treatment can be complex. Patients who've gone through treatment will often say your symptoms get worse before they get better.