Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol's Impact on Glutathione and Liver Damage Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Data summary: IL 4 regulates glutathione levels in the liver and lung Download Scientific Diagram