The Protective Effects of Garlic Extract Against Acetaminophen Induced Oxidative Stress and Glutathione Depletion Ferroptosis and Intrinsic Drug induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective Downregulation of Glutathione Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen Induced Liver Injury through IRE1 ER Stress Signaling Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.