Tylenol and Glutathione: A Closer Look At Their Relationship Researchers associate taking higher amounts of Tylenol while pregnant with language delays in early childhood : r science Acetaminophen Pathway (therapeutic doses), Pharmacokinetics Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect