Tylenol's Impact on Glutathione and Liver Damage Japanese Skin Care Premium Brands for Radiant Skin X Beauty Face Skincare Multi Brand Korean, Japanese & Chinese Products XBeauty Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Understanding the Impact of Acetaminophen: Tylenol and Glutathione in Autism