Acute acetaminophen paracetamol toxicity NAPQI an overview ScienceDirect Topics Acetaminophen metabolism and NAPQI mediated mitochondrial effects Download Scientific Diagram PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Paracetamol (Acetaminophen) hepatotoxicity and its management. 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins.