Vape Puffs vs Cigarettes: A Nicotine Comparison Clutch Vape How Many Puffs in a Vuse Alto Pod HV How Many Vape Puffs Is One Cigarette? ARR Brand A single vape cartridge can have the nicotine equivalent of 600 cigarettes. Vaping JUUL Seminole Prevention Coalition Nicotine use among young people is evolving. New research shows more youth are using multiple nicotine products at the same timemost commonly cigarettes and e cigarettes, with a growing rise in combining vapes