Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Your liver's unsung hero: Glutathione Let's talk about what really happens when you take Tylenol (acetaminophen). Your liver breaks down acetaminophen through several pathways. One pathway creates NAPQIa reactive compound that needs Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Use and Potential Benefits of N Acetylcysteine in Non Acetaminophen Acute Liver Failure: An Etiology Based Review Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health What to Avoid When Taking Glutathione 7 Crucial Facts