The multiple mechanisms and modes of cell death after acetaminophen overdose Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Glutathione, Alcohol and drugs g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram